FP1274 : EXCESS OF IMMUNOGLOBULINS – FRIEND OR FOE

Dr.PRATEEK JAIN

The hyper IgE syndromes are rare primary immune deficiencies characterized by elevated serum IgE, rash and recurrent bacterial infections of the skin and lung. We report a 8 yrs old male child who presented to us with c/o pain, redness and inability to open the eyes for 3 days. He had stromal infiltrate with hypopyon in RE with multiple molluscum nodules in both lids in BE. on review glue & BCL were applied as there was central corneal melt. corneal scrapping came as pseudomonas aeruginosa. child was on regular followup for 4 months and his corneal ulcer healed. He had CSOM with enterococcus and proteus miribilis growth on ear swabs. He also had pulmonary TB. Conjunctival swab also showed proteus species. He was treated with interferon α 2b injections. He was diagnosed to have systemic giant Molluscum with Hyper IgE /eosinophilia / cutaneous abscess with Dock and gene mutation and CD 3,4 deficiency. Patients with multiple infections immuno deficiencies should be considered