Dr.Dhrubojyoti Sarker
Purpose- Analyse the therapeutic efficacy between autologous serum eye drops diluted with saline and with Na hyaluronate in moderate to severe dry eyes.
Methods- 17 patients with dry eyes (mean Schirmer value 5.8+/- 1.2) included in this study. 10 ml serum prepared from each patient. Refrigerated for 1 week and defrosted marked samples diluted with 20% saline for randomly selected group A(9 cases) and diluted with 20% Na hyaluronate group B(8 cases)( 50-50 solution). Patients used drops 3 times daily and were assessed on weekly basis and serial improvement analysed.
Result- Initially, mean baseline values- visual acuity-0.76+/- 1.9(log MAR), Schirmer value 5.8+/-1.2, TBUT 6.5+/-2.4.after 2 months follow up group A values were- 0.77+/- 2.1, 6.8+/-3.4, 10.3+/-2.3, group B showed- 0.79+/-1.98, 11.8+/-2.2, 7.2+/-3.5 respectively.
Conclusion- Serum with Na hyaluronate reduces corneo conjunctival epithelial loss and tear film stability by growth factors in it and improves visual outcome.
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