Dr.SANDEEP KUMAR
Restoration of ocular surface intigrity & the limbal barrier by limbal stem cell transplantation is essential in patients with limbal stem cell deficiency.
Corneal epithelial cells from the surface are desquamated & replaced by proliferating basal epithelial cells from the periphery.
Stem Cells, residing within the palisades of Vogt at the limbus maintain the state of dynamic equilibrium by moving vertically & horizontally.
There is no direct markers for the stem cells.
These cells are poorly differentiated with a slow cell cycle, long life span & a high capacity for error-free self renewal.
The limbal stem cells are responsible for corneal epithelial renewal & regeneration & function as a barrier, preventing conjunctival epithelium from growing on to the cornea.
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