Dr.MUGUNDHAN RAJARAJAN
Aim:To investigate association of eye rubbing and MMP9 expression in the tear film of newly diagnosed early keratoconus patients .
Methods:This is a prospective interventional case control study comparing 40 newly diagnosed keratoconus patients with other 40 non keratoconus patients who had also come for refractive surgery done over 6 months. For everyone a Meticulous History taken&Clinical examination including MMP- 9 estimation with Inflamma Package Insert done.
Results :The eye rubbing rate was significantly higher in keratoconus group versus control nonkeratoconus group(65%[26/40] versus 7.5%[3/40]). MMP-9 was found to be positive in 77.5% keratoconus patients.
Conclusion : The non-invasive way of collecting the tears makes it an optimal biological fluid to study with minimal discomfort to the patient.Identification of inflammatory markers therefore, has paramount importance in Keratoconus patients, so that effective intervention can be done to improve the quality of life
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