FP1349 : Role of immunosuppressive therapy in Vogt-Koyanagi-Harada syndrome (VKH) in South Indian population

Dr.Pratyusha Ganne, Dr.HARSH MONE, Dr.S Bala Murugan, Dr. PANKAJA DHOBLE

VKH disease is an inflammatory disorder characterized by bilateral granulomatous panuveitis and extraocular manifestations. Here, we describe the presenting features, visual outcome, complications and recurrences of patient with VKH in a south Indian population. The exact role of immunosuppressive drugs in acute stage was analysed. 18 patients diagnosed as VKH in 2007-16 were evaluated retrospectively. 13 patients presented in the acute stage while five in the chronic phase. 6 Cases received steroid monotherapy (group 1) while 7 Cases received both steroids and immunosuppressive agents (group 2). Mean recurrence rate in Group 1 was 2,while that in Group 2 was 0.7 (P=0.006). In group 1 60% had multiple recurrences, while the same in group 2 was 30% (p=0.09). The incidence of serous retinal detachment as a marker of recurrence was higher in our Cases, than previously reported.