Dr.SUSHIL PATIL
Introduction: Acute promyelocytic Leukaemia is caused translocation between chromosome 17 and 15 leading to leukocyte differentiation at the promyelocyte stage. ATRA differentiates promyelocytes into mature granulocytes with remission.Benign intracranial hypertension(BIH) is likely due to vitamin A toxicity presenting with hemorrhagic coagulopathy and retinal hemorrhages.Patients developing ATRA-induced BIH, cessation or halving dosage leads to resolution of disc edema
Purpose:To report co-relation between development of Benign intracranial hypertensionand ATRA.
Methods:ATRA was lowered from 45mg/m2to 25mg/m2 with Acetazolamide with F/U one week,one and 3 months. Evaluation with fundus photos,FAF,OCT,OCTA and Bscan OU.
Result:Reduction of Papilloedema and sub-arachnoid fluid one and three months after ATRA was lowered with improvement in visual acuity.
Conclusion:Reduction of ATRA with acetazolamide is efficacious to treat intracranial hypertension in Acute Promyelocytic leukaemia.
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